Lpr Physiology Pdf !link! -

The refluxate in LPR is a complex milieu, and its composition is critical to tissue injury:

| Feature | GERD (Typical) | LPR (Atypical/Silent) | | :--- | :--- | :--- | | | Heartburn, Regurgitation | Hoarseness, Cough, Globus | | Mechanism | LES Failure, Supine Reflux | UES Dysfunction, Upright Reflux | | Tissue Type | Esophageal Squamous | Laryngeal Respiratory Epithelium | | Sensitivity | High tolerance (acid clearance) | Low tolerance (highly susceptible) | | pH Threshold | pH < 4 required for injury | Injury can occur at pH 4-5 (Pepsin) | | Diagnostic Gold Standard | Esophagogastroduodenoscopy (EGD) | Laryngoscopy / pH Monitoring (Hypopharyngeal) | lpr physiology pdf

on this topic:

Laryngopharyngeal reflux is the retrograde flow of gastric contents (acid and pepsin) beyond the esophagus into the larynx, pharynx, and sometimes the nasopharynx. Unlike classic Gastroesophageal Reflux Disease (GERD), which primarily affects the esophagus and causes heartburn, LPR is often "silent" because it frequently occurs without typical burning sensations. The refluxate in LPR is a complex milieu,