Use Rufus for USB bootable drives; use PowerISO for ISO editing and disc burning.
The primary difference is their scope: is a specialized, lightweight utility for creating bootable USB drives. PowerISO is a comprehensive disk image management suite that can create, edit, mount, and burn ISO files, in addition to creating bootable USBs. Quick Comparison: PowerISO vs. Rufus difference between power iso and rufus - Filo poweriso vs rufus