: A Z-score ≥ 2.0 is considered positive for aortic root dilation .
Marfan Syndrome (MFS) is an autosomal dominant genetic disorder affecting approximately 1 in 5,000 individuals worldwide. The condition primarily impacts the skeletal, ocular, and cardiovascular systems. The primary cause of morbidity and mortality in MFS is cardiovascular complications, specifically the dilation of the aortic root, which can lead to aortic dissection or rupture. marfan syndrome z score
The formula generally utilized is: $$Z = \frac{(X - \mu)}{\sigma}$$ Where: : A Z-score ≥ 2