Here is a comprehensive guide to fixing this error and stabilizing your gameplay. 1. Optimize In-Game Graphics Settings
High AA settings significantly increase VRAM usage. Disabling or lowering AA is often the fastest fix for this specific error. resident evil 6 out of video memory fix
RE6 is an older 32-bit game. It cannot use more than ~3.5GB of video memory, regardless of your GPU. Lowering settings is often the only reliable fix. Here is a comprehensive guide to fixing this