Rs6278

Research has linked rs6278 to several neuropsychiatric and behavioral phenotypes. Key associations found in scientific literature include:

rs6278 is often studied alongside the "TaqIA" polymorphism (rs1800497) and the functional variant rs1076560. While it does not change the amino acid sequence directly, researchers hypothesize that it may affect mRNA splicing efficiency or stability, leading to altered ratios of the long vs. short isoforms of the D2 receptor. rs6278

Because rs6278 lies in the 3’UTR, it does not change the amino acid sequence of the oxytocin receptor protein. Instead, it is believed to influence , potentially affecting mRNA stability, localization, or translation efficiency. It is often studied in linkage disequilibrium (LD) with another well-known OXTR SNP, rs53576 (though the linkage pattern varies across populations). Research has linked rs6278 to several neuropsychiatric and

: Evidence suggests rs6278 may be a factor in Anorexia Nervosa (AN) , particularly the purging type. short isoforms of the D2 receptor

: rs6278 is often studied as part of a 12kb haplotype block that spans both the DRD2 and ANKK1 genes.