If you're running Windows 10, you can also enable or disable the function key lock through the Windows Mobility Center:
For permanent control, especially on external Dell keyboards or older models:
If the keyboard shortcut doesn't work, or if you want to lock this setting so it never changes accidentally, you need to change it in the BIOS.
Hope this helps save you from a headache!
Some external Dell USB keyboards also support Fn Lock via Fn + Esc .
The Dell function key lock allows you to toggle between two modes for the top row of your keyboard. You can either use the standard F1-F12 functions or the multimedia "hotkeys" like volume and brightness control.